UniqueSmile™ PROBIOTICS (25 billion Active cells) “Scientifically formulated - backed by research”

Detail Description of Probiotics, Prebiotics, and Postbiotics

Oral Microbiome & Oral Wellness Support

  • Lactobacillus reuteri – Supports oral microbiota balance and overall oral health
  • Lactococcus lactis – Contributes to maintaining a balanced oral microbial environment
  • Lactobacillus paracasei – Supports oral health as part of a daily oral care routine
  • Lactobacillus rhamnosus – Supports a clean, healthy-feeling mouth

References

Lactobacillus reuteri

Meurman, J. H. & Stamatova, I. Probiotics: contributions to oral health. Oral Dis. 24, 92–99 (2018).

Krasse, P. et al. Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri. Swed. Dent. J. 30, 55–60 (2006).

Lactococcus lactis

Wescombe, P. A., Hale, J. D. F., Heng, N. C. K. & Tagg, J. R. Developing oral probiotics from Streptococcus salivarius. Future Microbiol. 7, 1355–1371 (2012). https://doi.org/10.2217/fmb.12.113
(Note: Discussion includes bacteriocin mechanisms relevant to Lactococcus lactis.)

Lactobacillus paracasei

Keller, M. K. & Twetman, S. Acid production in dental plaque after exposure to probiotic bacteria. BMC Oral Health 12, 13 (2012). https://doi.org/10.1186/1472-6831-12-44

Lactobacillus rhamnosus

Näse, L. et al. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res. 35, 412–420 (2001). https://doi.org/10.1159/000047484

Gum & Oral Wellness Support

  • Lactobacillus salivarius – Supports gum health and overall oral wellness
  • Lactobacillus brevis – Supports oral comfort and healthy gums
  • Bifidobacterium breve – Helps maintain a balanced oral microbiota
  • Bifidobacterium longum – Supports overall oral and gum health

References

Lactobacillus salivarius
Mayanagi, G. et al. Suppression of periodontal pathogenic bacteria in the saliva of humans by the administration of Lactobacillus salivarius TI 2711. J. Jpn. Soc. Periodontol. 45, 105–112 (2003). https://doi.org/10.2329/perio.45.105

Lactobacillus brevis
Jayachandra, M. Y., Gayathiri, R., Aruna, C. N., Bhat, P. K. & Arumugam, P. M. Clinical effects of Bifidobacterium as a probiotic on oral health: a systematic review. Dent. Res. J. (Isfahan) 20, 32 (2023).
Lee, J. K., Kim, S. J., Ko, S. H., Ouwehand, A. C. & Ma, D. S. Modulation of the host response by probiotic Lactobacillus brevis CD2 in experimental gingivitis. Oral Dis. 21, 705–712 (2015). https://doi.org/10.1111/odi.12332

Bifidobacterium breve
Beattie, R. E. Probiotics for oral health: a critical evaluation of bacterial strains. Front. Microbiol. 15, 1430810 (2024). https://doi.org/10.3389/fmicb.2024.1430810

Bifidobacterium longum
Matsubara, V. H., Fakhruddin, K. S., Ngo, H. & Samaranayake, L. P. Probiotic Bifidobacteria in managing periodontal disease: a systematic review. Int. Dent. J. 73, 11–20 (2023). https://doi.org/10.1016/j.identj.2022.11.018
Mahdizade Ari, M. et al. Investigating the antimicrobial and anti-inflammatory effects of Lactobacillus and Bifidobacterium spp. on cariogenic and periodontitis pathogens. Front. Microbiol. 15, 1383959 (2024). https://doi.org/10.3389/fmicb.2024.1383959 

Oral Freshness & Oral Wellness Support

  • Streptococcus salivarius – Supports oral microbiota balance and a fresh, clean mouthfeel
  • Lactobacillus reuteri – Supports overall oral health and oral freshness

References

Streptococcus salivarius 

Karbalaei, M. et al. Alleviation of halitosis by use of probiotics and their protective mechanisms in the oral cavity. New Microbes New Infect. 42, 100887 (2021). https://doi.org/10.1016/j.nmni.2021.100887
Huang, N. et al. Efficacy of probiotics in the management of halitosis: a systematic review and meta-analysis. BMJ Open 12, e060753 (2022). https://doi.org/10.1136/bmjopen-2022-060753

Lactobacillus reuteri
Chugh, P., Dutt, R., Sharma, A., Bhagat, N. & Dhar, M. S. A critical appraisal of the effects of probiotics on oral health. J. Funct. Foods 70, 103985 (2020). https://doi.org/10.1016/j.jff.2020.103985
Liu, Z. et al. The impact of Lactobacillus reuteri on oral and systemic health: a comprehensive review of recent research. Microorganisms 13, 45 (2024). https://doi.org/10.3390/microorganisms13010045 

Overall Oral Microbiome & Oral Wellness Support

  • Lactobacillus casei – Supports oral microbiota balance and overall oral wellness
  • Lactobacillus plantarum – Supports oral health as part of a daily oral care routine
  • Lactobacillus fermentum – Helps maintain a balanced oral microbial environment
  • Streptococcus thermophilus – Supports overall oral health and oral comfort

Lactobacillus casei

Lundtorp-Olsen, C., Markvart, M., Twetman, S. & Belstrøm, D. Effect of probiotic supplements on the oral microbiota: a narrative review. Pathogens 13, 419 (2024). https://doi.org/10.3390/pathogens13050419

Inchingolo, F. et al. The benefits of probiotics on oral health: systematic review of the literature. Pharmaceuticals 16, 1313 (2023). https://doi.org/10.3390/ph16091313

Kilian, M., Chapple, I., Hannig, M. et al. The oral microbiome—an update for oral healthcare professionals. Br. Dent. J. 221, 657–666 (2016). https://doi.org/10.1038/sj.bdj.2016.865

Caufield, P. W., Schön, C. N., Saraithong, P., Li, Y. & Argimón, S. Oral lactobacilli and dental caries: a model for niche adaptation in humans. J. Dent. Res. 94(9 Suppl), 110S–118S (2015). https://doi.org/10.1177/0022034515576052

Lactobacillus plantarum

Srivastava, N. et al. Lactobacillus plantarum 108 inhibits Streptococcus mutans and Candida albicans mixed-species biofilm formation. Antibiotics 9, 478 (2020). https://doi.org/10.3390/antibiotics9080478

Rizzo, A., Losacco, A., Romano Carratelli, C., Di Domenico, M. & Bevilacqua, N. Lactobacillus plantarum reduces Streptococcus pyogenes virulence by modulating IL-17, IL-23, and Toll-like receptor expressions in human epithelial cells. Int. Immunopharmacol. 17, 453–461 (2013). https://doi.org/10.1016/j.intimp.2013.07.005

Volgenant, C. M. C. et al. The evaluation of the effects of two probiotic strains on the oral ecosystem: a randomized clinical trial. Front. Oral Health 3, 825017 (2022). https://doi.org/10.3389/froh.2022.825017

Lactobacillus fermentum

Mishra, S., Rath, S. & Mohanty, N. Probiotics—A complete oral healthcare package. J. Integr. Med. 18, 462–469 (2020). https://doi.org/10.1016/j.joim.2020.08.005

Kawai, T. et al. Limosilactobacillus fermentum ALAL020, a probiotic candidate bacterium, produces a cyclic dipeptide that suppresses the periodontal pathogens Porphyromonas gingivalis and Prevotella intermedia. Front. Cell Infect. Microbiol. 12, 804334 (2022). https://doi.org/10.3389/fcimb.2022.804334

Streptococcus thermophilus

Kõll-Klais, P. et al. Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity. Oral Microbiol. Immunol. 20, 354–361 (2005). https://doi.org/10.1111/j.1399-302X.2005.00239.x

Gobbetti, M. & Calasso, M. Streptococcus | Introduction. In: Batt, C. A. & Tortorello, M. L. (eds) Encyclopedia of Food Microbiology (2nd ed.), 535–553 (Academic Press, 2014). https://doi.org/10.1016/B978-0-12-384730-0.00324-4

Lee, S. H. & Baek, D. H. Effects of Streptococcus thermophilus on volatile sulfur compounds produced by Porphyromonas gingivalis. Arch. Oral Biol. 59, 1205–1210 (2014). https://doi.org/10.1016/j.archoralbio.2014.07.006 

PREBIOTICS

L-Citrulline

L-Citrulline is a powerful amino acid that helps your body produce nitric oxide (NO), a key molecule that supports healthy circulation and heart function. By boosting NO levels, it relaxes and widens blood vessels, promoting better blood flow and helping to maintain healthy blood pressure. This improved circulation not only supports cardiovascular wellness but also enhances exercise performance by reducing muscle fatigue and aiding recovery. Studies have shown that L-Citrulline can improve energy, stamina, and overall vascular health, making it a valuable nutrient for both heart support and active lifestyles.

Role in Oral Wellness

  • Supports normal physiological processes in the oral cavity
  • Helps maintain oral microbiota balance
  • Supports healthy gum tissues as part of daily oral care
  • Supports overall oral comfort and wellness

Potential Oral Wellness Support

  • Supports overall oral health and wellness
  • Helps maintain a balanced oral microbiota
  • Supports oral comfort as part of a daily oral care routine

References

Schwedhelm, E. et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br. J. Clin. Pharmacol. 65, 51–59 (2008). https://doi.org/10.1111/j.1365-2125.2007.02980.x

Figueroa, A., Alvarez-Alvarado, S., Jaime, S.J. & Kalfon, R. L-citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight men. Br. J. Nutr. 116, 279–285 (2016). https://doi.org/10.1017/S0007114516001811

Pérez-Guisado, J. & Jakeman, P.M. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J. Strength Cond. Res. 24, 1215–1222 (2010). 

Inulin

Inulin is a naturally occurring, soluble dietary fiber commonly used to support digestive health and overall well-being. It helps support a balanced gut microbiota and participates in normal fermentation processes in the digestive system. Inulin supports normal gastrointestinal function and digestive comfort and is widely used in food and nutrition applications as part of a healthy diet.

References

Hughes, R.L., Alvarado, D.A., Swanson, K.S. & Holscher, H.D. The prebiotic potential of inulin-type fructans: a systematic review. Adv. Nutr. 13, 492–529 (2022). https://doi.org/10.1093/advances/nmab119

Liu, F., Prabhakar, M., Ju, J., Long, H. & Zhou, H.W. Effect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials. Eur. J. Clin. Nutr. 71, 9–20 (2017). https://doi.org/10.1038/ejcn.2016.156

Kolida, S. & Gibson, G.R. Prebiotic capacity of inulin-type fructans. J. Nutr. 137, 2503S–2506S (2007).

Fernandes, R. et al. Effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adult patients with overweight or obesity: a systematic review. Clin. Nutr. 36, 1197–1206 (2017). https://doi.org/10.1016/j.clnu.2016.10.003 

Inulin in Dental Probiotic Formulations

What It Is

Inulin is a naturally occurring, soluble dietary fiber commonly used in food and dietary supplement applications.

Role in Oral Care

  • Used as part of formulations designed to support oral microbiota balance
  • Included in oral care products to complement probiotic ingredients

Potential Oral Wellness Support

  • Helps maintain a balanced oral microbial environment
  • Supports overall oral health as part of a daily oral care routine

Synergistic Use in Dental Probiotic Formulations

Inulin may be combined with probiotic ingredients, such as Streptococcus salivarius, Lactobacillus reuteri, and Bifidobacterium lactis, as part of a comprehensive oral wellness formulation.

  • Supports overall oral wellness
  • Designed for use alongside daily oral hygiene practices

Prebiotic and Probiotic Formulation Approach

  • Combines non-digestible dietary fiber with probiotic ingredients
  • Intended to support a balanced oral microbiota
  • Suitable for inclusion in oral care and dietary supplement products

Postbiotics

Postbiotics are non-viable microbial components and metabolic byproducts generated during microbial fermentation. These materials may include organic acids, peptides, enzymes, and other microbial-derived components used in food and dietary supplement applications.

Postbiotics are valued for their stability, defined composition, and suitability for shelf-stable formulations. They have been studied for their role in supporting general wellness and are commonly incorporated into products without the need to maintain live microorganisms.

 

References

Hill, C. et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 11, 506–514 (2014). https://doi.org/10.1038/nrgastro.2014.66

Pimentel, T. C. et al. Postbiotics: an overview of concepts, inactivation technologies, health effects, and driver trends. Trends Food Sci. Technol. 138, 199–214 (2023). https://doi.org/10.1016/j.tifs.2023.06.009

Aguilar-Toalá, J. E. et al. Postbiotics: an evolving term within the functional foods field. Trends Food Sci. Technol. 75, 105–114 (2018). https://doi.org/10.1016/j.tifs.2018.03.009

Salminen, S. et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat. Rev. Gastroenterol. Hepatol. 18, 649–667 (2021). https://doi.org/10.1038/s41575-021-00440-6

 

Warnings & Disclaimers

*Dietary Supplement. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.