Molecular diagnostics that fit into your existing workflow
UniquePerioSignature™ gives your practice qPCR-based pathogen data in 2 working days - turning subjective probing into a defensible, data-backed periodontal risk classification you can act on chairside.
Contact us for pricingHow it fits into a patient visit
Comprehensive Exam
Perform your standard periodontal charting, radiographic analysis, and medical history/risk factor review.
Collect Sample
Have the patient provide a saliva sample chairside using SalivaPreserv™ - no bleeding, minimally invasive, 5 minutes.
Submit to Lab
Send the sample to our CLIA-certified facility (45D2313828). DNA remains stable for 14 days at room temperature.
Review Molecular Results
Receive quantified counts for Aa, Pg, Td, Tf, and Pi within 2 days, benchmarked against clinical reference ranges.
AI-Driven Treatment Insights
Leverage our advanced AI algorithms to generate personalized, evidence-based treatment considerations by seamlessly combining your clinical findings with precise molecular data and clinical symptoms.
Classify & Plan
Combine molecular results with your clinical findings using our Chairside Decision Tree to assign a risk tier and treatment path.
Treat & Reassess
Deliver in-office and home care guidance, then re-evaluate at the recommended interval (typically 4–8 weeks or 6 months).
Expert Clinician Support
Have questions about a complex case or specific lab results? Connect directly with our on-staff experts by phone for personalized guidance and report interpretation.
Risk classification drives the treatment plan
Molecular pathogen load is combined with your clinical findings (probing depth, bleeding on probing) to assign one of four risk tiers - each mapped to a specific treatment protocol.
| Risk Tier | Molecular Criteria | Clinical Criteria | Recommended Action |
|---|---|---|---|
| Low Risk | Aa & Pg not detected; Td/Tf/Pi within optimal range | PD <4mm, no BOP | Routine maintenance, reinforce hygiene, standard recall |
| Moderate Risk | Aa & Pg not detected; one or more of Td/Tf/Pi elevated | PD ≤3mm, no BOP | SRP, consider localized adjunctive therapy, re-evaluate in 4–8 weeks |
| High Risk | High Aa and/or Pg, or high Td/Tf/Pi | PD >4mm, no BOP | SRP, localized adjunctive therapy, re-evaluate in 4–8 weeks |
| Very High Risk | Synergistic high loads of the full microbial panel (Aa, Pg, Td, Tf, Pi) or any of the pathogens are in the high number. | PD >6mm, positive BOP | Comprehensive periodontal therapy, evaluate systemic therapy, consider periodontist referral |
Final classification is based on the highest risk level found in any single category to ensure a conservative, proactive approach to your care. This classification is a helpful reference tool, but the final diagnostic decision remains with your treating clinician. Your dentist will evaluate these results alongside your overall health profile, taking into account conditions like diabetes, high blood pressure, and other systemic diseases.
Move from visual assessment to quantified data
Probing depths and bleeding tell you where disease may be active - but not which pathogens are driving it, or how aggressively. UniquePerioSignature™ adds a quantitative layer: exact bacterial counts per mL of saliva, validated for accuracy, precision, and repeatability.
That means more defensible treatment decisions, clearer patient communication, and objective data to track response to therapy over time.
Also Applicable To
Mild inflammation around implants → mechanical debridement + occlusion check. Bone loss/deep probing → radiographic confirmation + debridement, guided by implant stability and radiographs, not lab results alone.
Consider coordinating with primary care providers when poor glycemic control, cardiovascular risk, or pregnancy complication risk is suspected.
Built-in reassessment protocol
After initiating treatment, retest at 4–8 weeks to evaluate pocket reduction, bleeding reduction, and clinical response - or retest at 6 months during routine recall for maintenance patients.
Success Indicators
Pocket reduction, bleeding reduction, reduced pathogen counts on re-testing.
If Disease Persists
Perform access surgery/laser debridement, coordinate with PCP if underlying triggers suspected, or formally refer to a periodontist.
Home Care Support
Recommend daily flossing/water flosser and UniqueSmile Probiotics™ to help patients maintain results between visits.
Bring molecular diagnostics into your practice
Join clinics using UniquePerioSignature™ to make periodontal treatment planning more precise, and more defensible.
Contact us for pricing