Molecular diagnostics that fit into your existing workflow
UniquePerioSignature™ gives your practice qPCR based pathogen data in 2 working days, turning subjective probing into a defensible, data backed periodontal risk classification you can act on chairside.
Contact us for pricingHow it fits into a patient visit
Comprehensive Exam
Perform your standard periodontal charting, radiographic analysis, and medical history/risk factor review.
Collect Sample
Have the patient provide a saliva sample chairside using SalivaPreserv™, no bleeding, minimally invasive, 5 minutes.
Submit to Lab
Send the sample to our CLIA certified facility (45D2313828). DNA remains stable for 14 days at room temperature.
Review Molecular Results
Receive quantified counts for Aa, Pg, Td, Tf, and Pi within 2 days, benchmarked against clinical reference ranges.
AI Driven Treatment Insights
AI-assisted clinical insights provide interpretive information based on molecular test results and relevant clinical information to support independent assessment by qualified healthcare professionals.
Classify & Plan
Combine molecular results with relevant clinical findings using the Chairside Decision Tree to support risk stratification and informed clinical assessment.
Treat & Reassess
Provide appropriate in-office and home-care considerations based on independent clinical judgment, with follow-up evaluation at clinically appropriate intervals.
Expert Clinician Support
Have questions about a complex case or specific laboratory results? Connect with our professional support team for assistance with understanding report findings and related scientific information.
Risk classification drives the treatment plan
Molecular pathogen levels may be considered alongside relevant clinical findings, such as probing depth and bleeding on probing, to support risk stratification and independent clinical assessment.
| Risk Tier | Molecular Criteria | Clinical Criteria | Clinical Considerations |
|---|---|---|---|
| Low Risk | Aa & Pg not detected; Td/Tf/Pi within optimal range | PD <4mm, no BOP | Routine maintenance, reinforce hygiene, standard recall |
| Moderate Risk | Aa & Pg not detected; one or more of Td/Tf/Pi elevated | PD ≤3mm, no BOP | SRP, consider localized adjunctive therapy, re-evaluate in 4 to 8 weeks |
| High Risk | High Aa and/or Pg, or high Td/Tf/Pi | PD >4mm, no BOP | SRP, localized adjunctive therapy, re-evaluate in 4 to 8 weeks |
| Very High Risk | Synergistic high loads of the full microbial panel (Aa, Pg, Td, Tf, Pi) or any of the pathogens are in the high number. | PD >6mm, positive BOP | Consider appropriate periodontal management, including whether adjunctive systemic therapy or specialist referral may be clinically appropriate, based on the patient's overall clinical presentation and independent professional judgment. |
Disclaimer: Final classification is based on the highest risk level found in any single category to ensure a conservative, proactive approach to your care. This classification is a helpful reference tool, but the final diagnostic decision remains with your treating clinician. Your dentist will evaluate these results alongside your overall health profile, taking into account conditions like diabetes, high blood pressure, and other systemic diseases.
Move from visual assessment to quantified data
Probing depths and bleeding tell you where disease may be active, but not which pathogens are driving it, or how aggressively. UniquePerioSignature™ adds a quantitative layer: bacterial counts per mL of saliva, validated for accuracy, precision, and repeatability.
This provides additional molecular information to support clinical assessment, facilitate patient communication, and enable comparison of quantitative bacterial levels over time.
Also Applicable To
Mild inflammation around implants leads to mechanical debridement plus occlusion check. Bone loss or deep probing calls for radiographic confirmation plus debridement, guided by implant stability and radiographs, not lab results alone.
Consider coordinating with primary care providers when poor glycemic control, cardiovascular risk, or pregnancy complication risk is suspected.
Quick answers for your practice
Is it appropriate to make treatment decisions based solely on molecular results?
No. UniquePerioSignature™ is an adjunctive diagnostic tool. It should be interpreted together with the full clinical assessment, including probing, radiographs, systemic health, and patient history, to form a treatment plan.
How accurate is the UniquePerioSignature™ Panel?
The assay is developed under clinical laboratory quality standards and has undergone analytical validation for limit of detection, linearity, and reproducibility. Exact performance metrics are available on request.
Why does UniquePerioSignature™ use qPCR instead of next generation sequencing?
qPCR provides direct quantitation of target DNA, faster turnaround, lower cost, and well established analytical robustness, making it more practical for routine, actionable diagnostics than broad NGS profiling.
Does a patient need a follow up test once treatment is complete?
Yes. Follow up testing is recommended to confirm microbial reduction and guide maintenance frequency. Typical practice is to retest 6 to 12 weeks post therapy.
Is UniquePerioSignature™ CLIA compliant?
Yes. Our laboratory operates under CLIA certified clinical laboratory standards, CLIA# 45D2313828.
Built in reassessment protocol
Following treatment, consider follow-up evaluation as clinically appropriate, such as at 4–8 weeks or during routine maintenance intervals. Clinical findings and quantitative bacterial levels may be compared over time to support ongoing clinical assessment.
Success Indicators
Pocket reduction, bleeding reduction, reduced pathogen counts on re testing.
If Disease Persists
Perform access surgery/laser debridement, coordinate with PCP if underlying triggers suspected, or formally refer to a periodontist.
Home Care Support
Encourage appropriate daily oral hygiene practices, such as flossing or use of a water flosser. UniqueSmile Probiotics® may also be considered as part of a daily oral wellness routine.
Bring molecular diagnostics into your practice
Join clinics using UniquePerioSignature™ to make periodontal treatment planning more precise, and more defensible.
Contact us for pricing